Two proteins that lessen blood flow in the brain may work together to slow the brain’s rate of removing amyloid beta (shown in this photo), a protein shown to build up into dangerous levels in Alzheimer’s patients.
Researchers published the results of a study in Nature Cell Biology. They believe it documents a link between reduction in blood flow and the amyloid beta buildup, which were previously unknown to be related.
“This is quite unexpected,” said the study’s lead author Dr. Berislav Zlokovic. “On the other hand, both of these processes are mediated by the smooth muscle cells along blood vessel walls, and we know that those are seriously compromised in patients with Alzheimer’s disease, so perhaps we shouldn’t be completely surprised.”
The new findings are the result of a seven-year collaboration between two laboratories. Heading up the University of Rochester’s Center for Neurodegenerative and Vascular Brain Disorders, Zlokovic focused on research investigating possible root causes of Alzheimer’s at the molecular level. After noting a similarity in gene research by cardiovascular scientists and those studying Alzheimer’s patients, Zlokovic teamed with Dr. Joseph Miano of Aab Cardiovascular Research Institute, who co-authored this study with him.
In Alzheimer’s patients, the blood system that normally easily flushes excess amyloids doesn’t do the job, allowing a harmful buildup of the protein, damaging brain cells.
The study looked at two proteins that when working together activate genes that inhibit the removal of the built-up toxic protein.
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